ACE-inhibition increases podocyte number in experimental glomerular disease independent of proliferation
نویسندگان
چکیده
منابع مشابه
ACE-inhibition increases podocyte number in experimental glomerular disease independent of proliferation
OBJECTIVE The objective of this article is to test the effects of angiotensin-converting enzyme (ACE)-inhibition on glomerular epithelial cell number in an inducible experimental model of focal segmental glomerulosclerosis (FSGS). BACKGROUND Although ACE-inhibition has been shown to limit podocyte loss by enhancing survival, little is known about its effect on podocyte number following an abr...
متن کاملPodocyte Biology in Glomerular Health and Disease
s Nephron 2016;132:245–291 DOI: 10.1159/000445271 257 ing childhood NS. Moreover, reductions in glomerular and podocyte SULF2 expression also corresponded with injury, while glucocorticoid treatment restored SULF2 in podocytes. Our data suggest that SULF2 plays an important role in glucocorticoid response in NS.
متن کاملStudy of chronic effect of Losartan in inhibition of kidney glomerular number and glomerular volume changes in uninephrectomized diabetic rats(Stereological study).
Background: Diabetic nephropathy is one of the cause of the end stage of renal disease (ESRD). Hyperglicemia activate intrarenal Renin-Angiotensin system and highly AngiotensinII is produced locally in glomeruli. In this research AT1(Angiotensin type 1) receptors blocked by Losartan and effects of this drug in inhibition of renal structural lesions were assessed quantitatively. Materials & me...
متن کاملDe novo expression of podocyte proteins in parietal epithelial cells during experimental glomerular disease.
Studies have shown that certain cells of the glomerular tuft begin to express proteins considered unique to other cell types upon injury. Little is known about the response of parietal epithelial cells (PEC) to injury. To determine whether PECs change their phenotype upon injury to also express proteins traditionally considered podocyte specific, the following four models of glomerular disease ...
متن کاملIntravital imaging of podocyte calcium in glomerular injury and disease.
Intracellular calcium ([Ca²⁺]i) signaling mediates physiological and pathological processes in multiple organs, including the renal podocyte; however, in vivo podocyte [Ca²⁺]i dynamics are not fully understood. Here we developed an imaging approach that uses multiphoton microscopy (MPM) to directly visualize podocyte [Ca²⁺]i dynamics within the intact kidneys of live mice expressing a fluoresce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the Renin-Angiotensin-Aldosterone System
سال: 2014
ISSN: 1470-3203,1752-8976
DOI: 10.1177/1470320314543910